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Gillian L Hirst, PhD

Gillian L Hirst, PhD

Assistant Professor
Division of General Surgery
Administrative Director
T32 Training Grant in Surgical Oncology



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University of Newcastle-upon Tyne, UK, BSc (Hons) Physiological Sciences 1991

University of Edinburgh, PhD. Molecular Oncology, 1995

  • University of Glasgow, UK, Molecular Oncology, 1995 - 2000
  • University of California, San Francisco, Genetics, Oncology 2000-2003
  • Biomarkers
  • Breast Cancer
  • Carcinogenesis
  • Drug Resistance
  • Genetic Risk
  • Precision Medicine
  • Tumor Biology

Gillian Hirst received her Ph.D. at the University of Edinburgh in the ICRF's (now CRUK) Molecular Oncology Unit, where she focused on the analysis and development of estrogen-regulated biomarkers for use in ovarian and breast cancers treated with anti-estrogenic therapies. As a postdoctoral fellow at CRUK Beatson Laboratories, University of Glasgow, she studied the molecular mechanisms of cisplatin resistance in ovarian cancer, with emphasis on the mismatch repair pathway. Building upon this work she studied the genetic susceptibility to DNA damaging agents in Allan Balmain's group here at UCSF. She has over ten years' experience working as a scientific program manager for multi-consortia projects and oversees biomarker development for the I-SPY2 TRIAL for early high-risk breast cancer, as well as multiple research initiatives within the Breast Care Center and the NIH Molecular Characterization of Screen-detected Lesions Consortium.

Dr. Hirst's areas of research interest span the continuum of disease risk in the analysis and development of biomarkers which will lead to better patient stratification and refined treatment interventions.

Data provided by UCSF Profiles, powered by CTSI at UCSF
  • CRC Post-Doctoral Fellowship, Beatson Institute, University of Glasgow, 1993-1999

Dr Hirst has over 15 years of research experience and managing scientific research programs. Her research interest particularly focuses on the molecular genetics of carcinogenesis, particularly as it relates to breast and ovarian cancer and understanding how we can better utilize biomarkers for risk stratification and treatment refinement. As Scientific Program Manager in the I-SPY2 TRIAL she oversees biomarker development and works with investigators from both academia and pharma to analyze data, tumor and liquid biopsy specimen using expression arrays, next-gen sequencing, multiplex-IHC and phospho-protein arrays.

As an investigator on a U01 which is part of the NIH Molecular Characterization of Screen-Detected Lesions (MCL) consortium, her research is focused on building tissue, pathology and imaging resources to assist in the better molecular definition of DCIS and defining who will recur with aggressive invasive cancer or not. The hope is to be able to stratify patients for either less treatment intervention or more at the earliest stages of disease, and to find potentially common drivers of aggressive disease across multiple disease types, as well as markers of indolent disease by looking at both tumor and stromal microenvironment biology.

Data provided by UCSF Profiles, powered by CTSI
  • I-SPY2 +: Evolving the I-SPY 2 TRIAL to include MRI-directed, adaptive sequential treatment to optimize breast cancer outcomes
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    Sep 2017
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    Aug 2022
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  • Elucidating the molecular and contextual basis for IDLE ultralow risk lesions and the tumor immune microenvironment of high risk in situ and invasive breast cancers
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    Sep 2015
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    Aug 2020
    Co-Investigator
  • Modeling the Impact of Targeted Therapy Based on Breast Cancer Subtypes
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    Sep 2014
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    Aug 2019
    Co-Investigator
  • Science Leadership and Integration
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    Sep 2009
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    Aug 2014
    Co-Investigator
  • A Systems Genetics Analysis of Cancer Risk, Progression and Therapeutic Response
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    Sep 1999
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    Mar 2014
    Co-Investigator
  • Program Project Grant
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    Sep 2003
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    Aug 2010
    Co-Investigator
MOST RECENT PUBLICATIONS FROM A TOTAL OF 32
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  1. Yee D, DeMichele AM, Yau C, Isaacs C, Symmans WF, Albain KS, Chen YY, Krings G, Wei S, Harada S, Datnow B, Fadare O, Klein M, Pambuccian S, Chen B, Adamson K, Sams S, Mhawech-Fauceglia P, Magliocco A, Feldman M, Rendi M, Sattar H, Zeck J, Ocal IT, Tawfik O, LeBeau LG, Sahoo S, Vinh T, Chien AJ, Forero-Torres A, Stringer-Reasor E, Wallace AM, Pusztai L, Boughey JC, Ellis ED, Elias AD, Lu J, Lang JE, Han HS, Clark AS, Nanda R, Northfelt DW, Khan QJ, Viscusi RK, Euhus DM, Edmiston KK, Chui SY, Kemmer K, Park JW, Liu MC, Olopade O, Leyland-Jones B, Tripathy D, Moulder SL, Rugo HS, Schwab R, Lo S, Helsten T, Beckwith H, Haugen P, Hylton NM, Van't Veer LJ, Perlmutter J, Melisko ME, Wilson A, Peterson G, Asare AL, Buxton MB, Paoloni M, Clennell JL, Hirst GL, Singhrao R, Steeg K, Matthews JB, Asare SM, Sanil A, Berry SM, Esserman LJ, Berry DA. Association of Event-Free and Distant Recurrence-Free Survival With Individual-Level Pathologic Complete Response in Neoadjuvant Treatment of Stages 2 and 3 Breast Cancer: Three-Year Follow-up Analysis for the I-SPY2 Adaptively Randomized Clinical Trial. JAMA Oncol. 2020 Jul 23. View in PubMed
  2. Douglas Yee, MD; Angela M. DeMichele, MD; Christina Yau, PhD; Claudine Isaacs, MD; W. Fraser Symmans, MD; Kathy S. Albain, MD; Yunn-Yi Chen, MD; Gregor Krings, MD; Shi Wei, MD; Shuko Harada, MD; Brian Datnow, MD; Oluwole Fadare, MD; Molly Klein, MD; Stefan Pambuccian, MD; Beiyun Chen, MD; Kathi Adamson, MD; Sharon Sams, MD; Paulette Mhawech-Fauceglia, MD; Anthony Magliocco, MD; Mike Feldman, MD; Mara Rendi, MD; Husain Sattar, MD; Jay Zeck, MD; Idris T. Ocal, MD; Ossama Tawfik, MD; Lauren Grasso LeBeau, MD; Sunati Sahoo, MD; Tuyethoa Vinh, MD; A. Jo Chien, MD; Andres Forero-Torres, MD; Erica Stringer-Reasor, MD; Anne M. Wallace, MD; Lajos Pusztai, MD; Judy C. Boughey, MD; Erin D. Ellis, MD; Anthony D. Elias, MD; Janice Lu, MD; Julie E. Lang, MD; Hyo S. Han, MD; Amy S. Clark, MD; Rita Nanda, MD; Donald W. Northfelt, MD; Qamar J. Khan, MD; Rebecca K. Viscusi, MD; David M. Euhus, MD; Kirsten K. Edmiston, MD; Stephen Y. Chui, MD; Kathleen Kemmer, MD; John W. Park, MD; Minetta C. Liu, MD; Olufunmilayo Olopade, MD; Brian Leyland-Jones, MD; Debasish Tripathy, MD; Stacy L. Moulder, MD; Hope S. Rugo, MD; Richard Schwab, MD; Shelly Lo, MD; Teresa Helsten, MD; Heather Beckwith, MD; Patricia Haugen, BS; Nola M. Hylton, PhD; Laura J. van’t Veer, PhD; Jane Perlmutter, PhD; Michelle E. Melisko, MD; Amy Wilson, BS; Garry Peterson, BS; Adam L. Asare, PhD; Meredith B. Buxton, PhD; Melissa Paoloni, MA; Julia L. Clennell, BA; Gillian L. Hirst, PhD; Ruby Singhrao, MS; Katherine Steeg, BA; Jeffrey B. Matthews, PhD; Smita M. Asare, BS; Ashish Sanil, PhD; Scott M. Berry, PhD; Laura J. Esserman, MD, MDA; Donald A. Berry, PhD.. Association of Event-Free and Distant Recurrence–Free Survival With Individual-Level Pathologic Complete Response in Neoadjuvant Treatment of Stages 2 and 3 Breast Cancer Three-Year Follow-up Analysis for the I-SPY2 Adaptively Randomized Clinical Trial. JAMA Oncology. 2020. View in PubMed
  3. Rozenblatt-Rosen O, Regev A, Oberdoerffer P, Nawy T, Hupalowska A, Rood JE, Ashenberg O, Cerami E, Coffey RJ, Demir E, Ding L, Esplin ED, Ford JM, Goecks J, Ghosh S, Gray JW, Guinney J, Hanlon SE, Hughes SK, Hwang ES, Iacobuzio-Donahue CA, Jané-Valbuena J, Johnson BE, Lau KS, Lively T, Mazzilli SA, Pe'er D, Santagata S, Shalek AK, Schapiro D, Snyder MP, Sorger PK, Spira AE, Srivastava S, Tan K, West RB, Williams EH. The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution. Cell. 2020 Apr 16; 181(2):236-249. View in PubMed
  4. Nanda R, Liu MC, Yau C, Shatsky R, Pusztai L, Wallace A, Chien AJ, Forero-Torres A, Ellis E, Han H, Clark A, Albain K, Boughey JC, Jaskowiak NT, Elias A, Isaacs C, Kemmer K, Helsten T, Majure M, Stringer-Reasor E, Parker C, Lee MC, Haddad T, Cohen RN, Asare S, Wilson A, Hirst GL, Singhrao R, Steeg K, Asare A, Matthews JB, Berry S, Sanil A, Schwab R, Symmans WF, van 't Veer L, Yee D, DeMichele A, Hylton NM, Melisko M, Perlmutter J, Rugo HS, Berry DA, Esserman LJ. Effect of Pembrolizumab Plus Neoadjuvant Chemotherapy on Pathologic Complete Response in Women With Early-Stage Breast Cancer: An Analysis of the Ongoing Phase 2 Adaptively Randomized I-SPY2 Trial. JAMA Oncol. 2020 Feb 13. View in PubMed
  5. Rose Li Y, Halliwill KD, Adams CJ, Iyer V, Riva L, Mamunur R, Jen KY, Del Rosario R, Fredlund E, Hirst G, Alexandrov LB, Adams D, Balmain A. Mutational signatures in tumours induced by high and low energy radiation in Trp53 deficient mice. Nat Commun. 2020 01 20; 11(1):394. View in PubMed
  6. View All Publications

 

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