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Andrew M. Posselt, M.D., Ph.D., FACS
- Professor of Surgery
- Division of Transplant Surgery
- Director, Pancreatic Islet Transplant Program
Contact Information
Academic Office
(415) 514-5606
[email protected]
(415) 514-5606
[email protected]
Education
- Stanford University, B.S., Biology, 1981-85
- University of Pennsylvania, M.D., Medicine, 1985-93
- University of Pennsylvania, Ph.D., Immunology, 1989-93
Residencies
- University of California, San Francisco, Resident, Medicine, 1993-96
- University of California, San Francisco, Resident, Surgery, 1996-00
Clinical Expertise
- Autologous Islet Cell Transplantation
- Bariatric Surgery (Laparoscopic and Open)
- Bile Duct Injuries
- Bile Duct Strictures
- Choledochal Cyst Disease
- End-Stage Kidney Disease
- Fulminant Hepatic Failure
- Hepatitis B
- Hepatitis C
- Hepatocellular Carcinoma (Primary Liver Cancer)
- Islet Cell Transplantation
- Kidney Transplantation
- Laparoscopic Donor Nephrectomy
- Liver Cysts
- Liver Transplantation
- Nonalcoholic Fatty Liver Disease
- Pancreas Transplantation
- Pediatric Kidney Transplantation
- Pediatric Liver Transplantation
- Portal Hypertension
Research Interests
- Assessment of long-term clinical outcomes in kidney donors
- Clinical outcomes of bariatric surgery in patients with end-stage kidney or liver disease
- Metabolic and biochemical consequences of bariatric surgery
- Transplantation of pancreatic islets as treatment for type 1 diabetes mellitus
Biography
Dr. Andrew Posselt is an attending multi-organ transplant surgeon at UCSF and Director of the ABO-Incompatible Kidney Transplant Program as well as Co-director of the Pancreatic Islet Transplant Program and the Bariatric Surgery Program. Dr. Posselt specializes in adult and pediatric kidney, liver and pancreas transplantation; laparoscopic donor nephrectomy; and laparoscopic as well as open bariatric surgery. Dr. Posselt's current research interests include: 1) transplantation of pancreatic islets for the treatment of type 1 diabetes mellitus; 2) assessment of long-term renal function in kidney donors after donor nephrectomy; 3) immunologic and tolerogenic properties of embryonic stem cells; and 4) bariatric surgery in patients awaiting transplant.
Research & Funding
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- Vertical Sleeve Gastrectomy for Treatment of NASH: a pilot randomized controlSponsor: NIHSponsor ID: R01DK128325Funding Period:Jul 2021-May 2024Co-Principal Investigator
- Treatment of Type I Diabetes by Islet Transplantation into the Gastric SubmucosaSponsor: NIH/NIDDKSponsor ID: R01DK098581Funding Period:May 2014-Apr 2020Principal Investigator
- "Advancing Islet Transplant for Type 1 Diabetes Care"Sponsor: NIH/NIDDKSponsor ID: U01DK085531Funding Period:Sep 2009-Jul 2013Principal Investigator
- Effect of Obesity on Long-Term Clinical Outcomes after Kidney DonationSponsor: NIH/NIDDKSponsor ID: R21DK078702Funding Period:Sep 2009-Jun 2012Principal Investigator
Clinical Trials
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- Study ID: NCT02402439Start Date: Mar 2016Estimated Completion Date: Jan 2021Condition(s): Diabetes, Diabetes Type 1
- Study ID: NCT01571817Start Date: Apr 2012Estimated Completion Date: Dec 2014Condition(s): Diabetes, Diabetes Type 1
- Study ID: NCT01369082Start Date: May 2011Estimated Completion Date: Jul 2017Condition(s): Diabetes, Diabetes Type 1, Islet Transplantation
- Study ID: NCT00434811Start Date: Oct 2006Estimated Completion Date: May 2014Condition(s): Diabetes, Diabetes Type 1
- Study ID: NCT00434850Start Date: Oct 2006Estimated Completion Date: Nov 2013Condition(s): Diabetes, Diabetes Type 1
Publications
MOST RECENT PUBLICATIONS FROM A TOTAL OF 113
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- Downs EM, Eaton A, Witkowski P, Wijkstrom M, Walsh M, Trikudanathan G, Singh VK, Schwarzenberg SJ, Pruett TL, Posselt A, Naziruddin B, Nathan JD, Mokshagundam SP, Morgan K, Lara LF, Gardner TB, Freeman ML, Ellery K, Chinnakotla S, Beilman GJ, Adams D, Ahmad S, Abu-El-Haija M, Bellin MD. Nutritional Risks in Patients Undergoing Total Pancreatectomy Islet AutoTransplantation in the POST Consortium. J Gastrointest Surg. 2023 09; 27(9):1893-1902. View in PubMed
- Wisel SA, Posselt AM, Szot GL, Nunez M, Santos-Parker K, Gardner JM, Worner G, Roll GR, Syed S, Kelly Y, Ward C, Tavakol M, Johnson K, Masharani U, Stock PG. A Multi-Modal Approach to Islet and Pancreas Transplantation With Calcineurin-Sparing Immunosuppression Maintains Long-Term Insulin Independence in Patients With Type I Diabetes. Transpl Int. 2023; 36:11367. View in PubMed
- Wu KC, Cao S, Weaver CM, King NJ, Patel S, Kim TY, Black DM, Kingman H, Shafer MM, Rogers SJ, Stewart L, Carter JT, Posselt AM, Schafer AL. Intestinal Calcium Absorption Decreases After Laparoscopic Sleeve Gastrectomy Despite Optimization of Vitamin D Status. J Clin Endocrinol Metab. 2023 01 17; 108(2):351-360. View in PubMed
- Santandreu AG, Taheri-Tehrani P, Feinberg B, Torres A, Blaha C, Shaheen R, Moyer J, Wright N, Szot GL, Fissell WH, Vartanian S, Posselt A, Roy S. Characterization of human islet function in a convection-driven intravascular bioartificial pancreas. Bioeng Transl Med. 2023 Mar; 8(2):e10444. View in PubMed
- Witkowski P, Philipson LH, Buse JB, Robertson RP, Alejandro R, Bellin MD, Kandeel F, Baidal D, Gaglia JL, Posselt AM, Anteby R, Bachul PJ, Al-Salmay Y, Jayant K, Perez-Gutierrez A, Barth RN, Fung JJ, Ricordi C. Islets Transplantation at a Crossroads - Need for Urgent Regulatory Update in the United States: Perspective Presented During the Scientific Sessions 2021 at the American Diabetes Association Congress. Front Endocrinol (Lausanne). 2021; 12:789526. View in PubMed
- View All Publications
Videos
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- Kidney Transplant Update - Donor Risks and Outcomes
- 2009 Liver Transplant Update: New Treatment for Hepatocellular Carcinoma, Bariatric Surgery and Liver Transplant
- 2010 Kidney Transplant Update: Bariatric Surgery for Transplant Candidates, Novel Therapies for Gastroparesis
- Islands in the (Blood) Stream: Update on Pancreas and Islet Transplantation
In the News
- UCSF Department of Surgery - October 14, 2022Congrats to Dr. Posselt for winning the 4th place prize in the Nikon Small World 2022 Photomicrography Competition. View Dr. Posselt's winning submission ›› The Nikon Small World Competition first began in 1975 as a means to recognize and applaud the efforts of those involved with photography through the light microscope. Since then, Small World has become a leading showcase for photomicrographers from the widest array of scientific disciplines and annually attracts nearly 2000 entries [...]
- UCSF Bariatric Surgery - - December 26, 2017UCSF Medical Center has been reaccredited as a "Comprehensive Center" for bariatric surgery by the American College of Surgeons (ACS) Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) and American Society for Metabolic and Bariatric Surgery (ASMBS). The UCSF Bariatric Surgery Center offers a full range of surgical weight-loss options, including laparoscopic and open Roux-Y gastric bypass, laparoscopic sleeve gastrectomy, and laparoscopic and open revisional [...]
- UCSF Bariatric Surgery - January 07, 2017Andrew Posselt, MD, PhD is a transplant and bariatric surgeon and professor of surgery at UCSF. Dr. Posselt performs kidney, liver, pancreas and islet transplants. He is also among a handful surgeons in the country who also performs bariatric surgery for patients who would otherwise be transplant candidates, but for their BMI and weight. Dr. Posselt is also director the pancreatic islet transplantation program and as a surgeon-scientist conducts breakthrough research in islet [...]
- UCSF Transplant Surgery - July 07, 2014In another demonstration of the Department of Surgery's commitment to global health and outreach, UCSF transplant surgeon Andrew M. Posselt, M.D., Ph.D., recently travelled to Cali, Colombia to help lay the groundwork for a laparoscopic donor nephrectomy program at the Fundacion Clinica Valle del Lili, a leading hospital in the region. Working with the transplant division chief Dr. Juan Pablo Carbonell Caicedo and his colleague Dr. Gabriel Jaime Echeverri, Dr. Posselt and the hospital's [...]
- UCSF Transplant Surgery - November 14, 2013UCSF News, reporting on the 14th World Congress of the International Pancreas and Islet Transplant Association (IPITA), highlighed improving results in islet cell transplantation: For the worst cases of type 1 diabetes, islet transplantation already has freed hundreds of people from complete dependence on insulin and from life-threatening consequences of the disease. "However, the procedure still is regarded as experimental by the U.S. Food and Drug Administration (FDA). Islets are [...]
- UCSF Transplant Surgery - June 14, 2012Liver cancer patients in need of an organ transplant often face a cruel reality -- while waiting for a deceased-donor liver, their cancer may worsen, spreading to other organs and making them ineligible for a transplant. With two children to raise and time ticking down, Amy Baghdadi was fast running out of options. But at her daughter's soccer practice, a fellow parent, who happened to be UCSF transplant surgeon, Andrew Posselt, M.D., Ph.D., heard Amy's story, and convinced there were other [...]
- UCSF Transplant Surgery - March 15, 2012"Neither man had a donor who was a match. But each had a family member willing to donate a kidney to a stranger, allowing them all to be part of chain which would, in turn, give Baty and Cienfuegos kidneys from other strangers. With 17 participating hospitals in 11 states, the chain consisted of 30 people willing to give up their kidney, matched with 30 more who needed one to survive. UCSF surgeons Andrew Posselt, M.D., Ph.D. and Ryutaro Hirose, M.D., performed the transplants on Baty and [...]
- UCSF Transplant Surgery - - October 30, 2011Alison Wesley received her diagnosis of Type 1 diabetes when she was just 11 years old, after she developed the classic symptoms of the disease – severe weight loss, excessive thirst, sugar cravings, frequent urination, and feeling lethargic. To treat the diabetes, doctors put her on the first generation of insulin pumps. She continued to use the pumps off and on until she was in her early 30s. But eventually, even the pumps could no longer help her control her glucose. "I developed 'brittle [...]
- UCSF Bariatric Surgery - September 27, 2011UCSF has been accredited by the American College of Surgeons (ACS) as a Level 1 Accredited Bariatric Center (ACS BSCN). The American College of Surgeons Bariatric Surgery Center Network Accreditation Program (ACS BSCN) accredits facilities in the United States that have undergone an independent, voluntary and rigorous peer evaluation in accordance with nationally recognized bariatric surgical standards. This adds to the prestige of the program which previously also earned the Blue [...]
Patient Stories
- Lorelei Batty
A Complex Procedure for Life-Threatening Pancreatitis
A Complex Procedure for Life-Threatening Pancreatitis One morning in December 2014, Lorelei Batty woke up screaming in pain and sick to her stomach. Emergency room doctors in her hometown of Santa Maria, Calif., thought the 3-year-old had the flu and sent her home. But Lorelei didn't improve over the next week and a half, and a far more serious diagnosis soon came in: pancreatitis, an inflammation of the pancreas that's rare in children and can be difficult to treat. After spending most of the next nine months in seven different hospitals with deteriorating health, Lorelei finally[...]