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Valerie M. Weaver, Ph.D.

Valerie M. Weaver, Ph.D.

Professor of Surgery
Departments of Surgery, Anatomy, and Bioengineering & Therapeutics Sciences
Director, Center for Bioengineering & Tissue Regeneration
Co-Director, Bay Area PSOC
Co-Director, UCSF Brain TMEN Program

Contact Information

513 Parnassus Avenue, Room HSE 560
San Francisco, CA 94143-0456
Telephone: 415-476-3826
Fax: 415-476-3985
http://weaverlab.ucsf.edu 
Valerie.Weaver@ucsf.edu
 
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University of Ottawa, Canada, B.Sc. (Honors), 1986
University of Ottawa, Canada, Ph.D., 1992

  • Institute for Biological Sciences, National Research Council of Canada, Postdoctoral Fellow, Molecular Cell Biology, 1992-94
  • Lawrence Berkeley National Laboratory, UC Berkeley, Postdoctoral Fellow, Cancer and Cell Biology, 1994-98

Valerie M. Weaver, Ph.D., is the Director of the Center for Bioengineering and Tissue Regeneration in the Department of Surgery. She earned her Bachelor of Science degree at the University of Waterloo in Biochemistry/Chemistry in 1985, continuing her education for an Honors Bachelor of Science in Biochemistry at the University of Ottawa (graduating Summa cum Laude). Dr. Weaver earned her doctorate degree, Ph.D, from the University of Ottawa in Biochemistry in 1992.

After receiving her doctorate, Dr. Weaver was awarded the Molecular Cell Biology and Apoptosis Research Group and the Institute for Biological Sciences of Canada Postdoctoral Fellow from 1992-1994.  From 1994-1998, she was distinguished as the Postdoctoral Fellow at the Lawrence Berkeley National Laboratory at the University of California, Berkeley, in the Cancer and Cell Biology Group, Life Sciences Division.

Following her fellowships, Dr. Weaver has held principle positions within academia. Prior to her appointment at UCSF, she was an Adjunct Associate Professor with the Department of Bioengineering at the University of Pennsylvania from 1999 to 2006. In her current position, she is an Professor with the Department of Surgery at the Universality of California, San Francisco.

Additionally, Dr. Weaver is the Director for the Center for Bioengineering & Tissue Regeneration with the Department of Surgery and UCSF, an Associate Professor in the Department of Anatomy at UCSF, and Adjunct Associate Professor for the department of Bioengineering at UPenn. From 1999 to 2006 she was a member at the Institute for Medicine and Engineering at UPenn.

Dr. Weaver's extensive honors and awards include: the Breast Cancer Scholar Award with the Department of Defense, the International Society of Differentiation Young Investigator Travel Award, the Alberta Heritable Foundation for Medical Research Lecturer Award, and the University of California Breast Cancer Research Program Postdoctoral Grant.

She also proudly serves on the Editorial Board for Cancer Biology & Therapy, was a guest editor in 2004 for J. Mammary Gland Biology and Neoplasia, and is currently an Ad Hoc Reviewer for several distinguished journals, including: Cancer Research, American Journal of Cell Biology, European Journal of Cell Biology, Molecular Carcinogenesis, Journal of the National Cancer Institute, Oncogene, FASEB Journal, Journal of Cell Science, Laboratory Investigation, Cancer Letters, Breast Cancer Research, Journal of Biological Chemistry, Molecular Biology of the Cell, Molecular and Cellular Biology, & Clinical Cancer Research. 

Dr. Weaver has over 20 years of experience in leading interdisciplinary research in oncology, including leadership of significant program projects merging approaches in the physical/engineering sciences and biology.  Her research focuses on the contribution of force, cell-intrinsic as well as extracellular matrix, to oncogenesis and tumor development. Her group employs 2- and 3-D in vitro cell culture techniques, clinical samples and animal models with force application techniques, and traction force and atomic force microscopy to assess the influence of the mechanical aspects of the cell environment on cell behavior and tumor progression. Dr. Weaver has been awarded many distinctions for her work demonstrating the critical importance of tissue structure in the treatment response of tumors, including the prestigious Department of Defense Era of Hope Breast Cancer Scholar Award for her innovative interdisciplinary research efforts on the effect of mechanical force on breast cancer progression and treatment response. Along with Dr. Jan Liphardt, PhD, UC Berkeley, she was awarded the prestigious Physical Sciences and Oncology Center Grant, whose aim is to integrate physical sciences approaches toward better understanding tumor biology. The Center encompasses close to 100 investigators in physics, engineering, mathematics, chemistry, cell and molecular biology, and clinical sciences from UC Berkeley, UCSF, and LBNL. In addition, Dr. Weaver a Co-PI on an NIH U01 grant with Dr. Werb on environmental stressors in mammary gland development and a Co-PI with Drs. Kalluri and Moses on role of fibroblasts, myeloid cells and matrix in PDAC.

Dr. Weaver is the TMEN-BCC co-PI with Dr. Bergers, as well as the leader of Project 3,in which she is testing the hypothesis that the mechanoproperties of SVZ-derived GBM, together with elevated cranial pressure and ECM stiffness, promote GBM aggressiveness and recurrence, in part by affecting the vascular and tumor stem cell compartment.

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  • Targeting the Cancer Glycocalyx
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    Mar 2019
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    Feb 2024
    Co-Principal Investigator
  • Reorienting the Glioblastoma Microenvironment to Respond to Immunotherapy
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    Feb 2019
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    Jan 2024
    Co-Principal Investigator
  • Tissue Tension, RANK and Breast Cancer Risk
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    Feb 2018
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    Jan 2023
    Principal Investigator
  • ECM geometrical and mechanical properties modulate RTK signaling
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    Sep 2015
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    Aug 2020
    Co-Principal Investigator
  • Tension-Stat3-miR-mediated metastasis
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    Apr 2015
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    Mar 2020
    Principal Investigator
  • A biophysical stromal basis for radiation sensitivity in ductal carcinoma in situ
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    May 2014
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    Feb 2019
    Co-Principal Investigator
  • Inside-Out Approaches to Improve Wound Repair by HoxB3
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    Jul 2016
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    Apr 2018
    Principal Investigator
  • Advanced Methods to Evaluate Extracellular Matrix and Crosslinking in the Tumor M
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    May 2014
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    Apr 2017
    Co-Principal Investigator
  • Biophysical and molecular dialogue of glioma cells and the brain microenvironment
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    Sep 2011
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    Jul 2016
    Co-Principal Investigator
  • 2015 Fibronectin, Integrins &Related Molecules Gordon Research Conference &Gordon Research Seminar
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    May 2015
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    Apr 2016
    Principal Investigator
  • TGF-beta Suppression and Promotion of Mammary Carcinomas
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    May 2000
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    Feb 2016
    Co-Principal Investigator
  • Role of Fibroblasts, Myeloid Cells and Matrix in PDAC
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    Sep 2010
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    Aug 2015
    Co-Principal Investigator
  • Fundamental Mechanobiology of Tumor Progression
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    Sep 2009
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    Jul 2015
    Co-Investigator
  • Collagen remodeling and tumor progression
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    May 2010
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    Feb 2015
    Principal Investigator
  • 2013 Fibronectin, Integrins &Related Molecules GRC/GRS
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    Feb 2013
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    Jan 2014
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  • NFkB, tissue polarity and apoptosis resistance
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    Jul 2000
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    Jun 2010
    Principal Investigator
MOST RECENT PUBLICATIONS FROM A TOTAL OF 141
Data provided by UCSF Profiles, powered by CTSI
  1. Piersma B, Hayward MK, Weaver VM. Fibrosis and cancer: A strained relationship. Biochim Biophys Acta Rev Cancer. 2020 Apr; 1873(2):188356. View in PubMed
  2. Ayad NME, Weaver VM. Tension in tumour cells keeps metabolism high. Nature. 2020 02; 578(7796):517-518. View in PubMed
  3. Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, Fearon D, Greten FR, Hingorani SR, Hunter T, Hynes RO, Jain RK, Janowitz T, Jorgensen C, Kimmelman AC, Kolonin MG, Maki RG, Powers RS, Puré E, Ramirez DC, Scherz-Shouval R, Sherman MH, Stewart S, Tlsty TD, Tuveson DA, Watt FM, Weaver V, Weeraratna AT, Werb Z. A framework for advancing our understanding of cancer-associated fibroblasts. Nat Rev Cancer. 2020 03; 20(3):174-186. View in PubMed
  4. Buffone A, Weaver VM. Don't sugarcoat it: How glycocalyx composition influences cancer progression. J Cell Biol. 2020 01 06; 219(1). View in PubMed
  5. Muncie JM, Falcón-Banchs R, Lakins JN, Sohn LL, Weaver VM. Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics. J Vis Exp. 2019 09 28; (151). View in PubMed
  6. View All Publications

 

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