Biography
Mackersie is a certified by the American Board of General Surgery, general certificate with subspecialty in surgical critical care. His practice is in general and trauma surgery, which includes vascular and thoracic surgery. In addition, he is a regular attending on the Surgical Critical Care Service at Zuckerberg San Francisco General Hospital and Trauma Center and serves as Vice-Chief of Surgery there.
Dr. Mackersie is a graduate of UC Berkeley and Michigan State University Medical School. He completed his internship, residency and chief residency training in general surgery and surgical critical care at the University of California, San Francisco, where he continued his specialty training and completed a trauma research fellowship. Dr. Mackersie joined the faculty at the University of California, San Diego University Hospital from 1985-1991.
Dr. Mackersie was appointed the Trauma Medical Director in 1992 at the University of California/San Francisco General Hospital (now Zuckerberg San Francisco General) and has been instrumental in expanding the multidisciplinary activities related to the Trauma Program. Dr. Mackersie currently serves as an officer for several surgical organizations and is a Governor of the American College of Surgeons. Dr. Mackersie has been appointed Secretary/Treasurer for the American Association for the Surgery of Trauma. Dr. Mackersie has also expanded the Trauma Nurse Practitioner program, and has progressed in developing the first aero-medical transport facility at San Francisco General Hospital. He has also been appointed Commissioner for the State of California Emergency Medical Services Authority, which is appointed by the Governor/California Speaker of the House.
Dr. Mackersie continues to direct the national program in Trauma System Planning and Evaluation for the American College of Surgeons, which includes the development of national benchmarks for trauma systems and trauma centers, and the creation of national guidelines for trauma systems development.
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
University of California, San Francisco | Residency | School of Medicine |
Board Certifications
- American Board of Surgery, 1986
- American Board of Surgery, Surgical Critical Care, 1988
Clinical Expertise
General Surgery
Surgical Critical Care
Trauma Surgery
Vascular Surgery
In the News
Research Narrative
- Inflammatory Lung Injury following major injury: One of the main areas of focus has been post-traumatic inflammatory lung injury. This collaborative research effort has continued, with new reports of the clinical syndrome of ARDS (ref # 63), the impact of ARDS on specific outcomes (ref # 62), and a recent report examining surrogate serum markers predictive of inflammatory lung injury. (ref # 65). The most recent work, still in preparation (Abstract, WIP ref # 3), attemps to link elements of inflammation with post-traumatic coagulopathy, and to better define the nature of early coagulopathy (pre-massive transfusion) that follows shock, traumatic brain injury, and major organ injury.
- Ventilatory management of patients with ARDS (refs # 66,67). Technical clinical studies performed in ICU patients with ARDS that attempt to expand our understanding of "optimal" modes of lung protective ventilation (LPV) in the setting or acute lung injury. LPV strategies are one of the few, if not the only demonstrable intervention having an impact on the outcome from ARDS over the past 15 years.
- Violence prevention recidivism (Abstracts/WIP ref # 1). Work in progress, this is part of an ongoing clinical and programmatic study that screens victims of youth violence & assesses the likelihood of recidivism. "High risk" patients are then referred into a program linking hospital services with post-discharge neighborhood/community services for violence prevention. A randomized study is being designed to compare recidivism outcomes with and without programmatic influence.
Research Interests
- Trauma systems development
- Inflammatory lung injury following major injury
- Ventilatory management of patients with ARDS
- Violence Prevention
Publications
- Pain Assessment in Older Adults After Traumatic Injury.| | PubMed
- Is state trauma funding associated with mortality among injured hospitalized patients?| | PubMed
- Characterizing re-triage guidelines: A scoping review of states' rules and regulations.| | PubMed
- Does Trauma Center Volume Account for the Association Between Trauma Center Verification Level and In-Hospital Mortality among Children Injured by Firearms in California?| | PubMed
- Re-triage moderates association between state trauma funding and lower mortality of trauma patients.| | PubMed
- Corrigendum to Surviving traumatic injury, only to die of acute drug poisoning: Should trauma centers be a path for intervention? [Surgery 170 (2021) pp 1249-54].| | PubMed
- Geographic Disparities in Re-triage Destinations Among Seriously Injured Californians.| | PubMed
- Defining obstacles to emergency transfer of trauma patients: An evaluation of retriage processes from nontrauma and lower-level Illinois trauma centers.| | PubMed
- The Association of Limited English Proficiency With Morbidity and Mortality After Trauma.| | PubMed
- Association of Race/Ethnicity With Substance Use Testing After Trauma: A Cross-Sectional Study.| | PubMed
- Limited English Proficiency Associated With Suboptimal Pain Assessment in Hospitalized Trauma Patients.| | PubMed
- Inequity in discharge pain management for trauma patients with limited English proficiency.| | PubMed
- Surviving traumatic injury, only to die of acute drug poisoning: Should trauma centers be a path for intervention?| | PubMed
- The DISTANCE study: Determining the impact of social distancing on trauma epidemiology during the COVID-19 epidemic-An interrupted time-series analysis.| | PubMed
- Emergency general surgery utilization and disparities during COVID-19: an interrupted time-series analysis.| | PubMed
- Describing the density of high-level trauma centers in the 15 largest US cities.| | PubMed
- F. William Blaisdell, MD: A leader for all time.| | PubMed
- Pelvic fracture pattern predicts the need for hemorrhage control intervention-Results of an AAST multi-institutional study.| | PubMed
- Reconsidering the Resources Needed for Multiple Casualty Events: Lessons Learned From the Crash of Asiana Airlines Flight 214.| | PubMed
- Current management of hemorrhage from severe pelvic fractures: Results of an American Association for the Surgery of Trauma multi-institutional trial.| | PubMed
- The Triage of Injured Patients: Mechanism of Injury, Regardless of Injury Severity, Determines Hospital Destination.| | PubMed
- Cervical spine clearance protocols in Level I, II, and III trauma centers in California.| | PubMed
- Recent developments in the assessment of the multiply injured trauma patient.| | PubMed
- Beyond emergency surgery: redefining acute care surgery.| | PubMed
- For the Care of the Underserved.| | PubMed
- Variability in California triage from 2005 to 2009: a population-based longitudinal study of severely injured patients.| | PubMed
- Cervical spine clearance protocols in level 1 trauma centers in the United States.| | PubMed
- Evaluating age in the field triage of injured persons.| | PubMed
- The forgotten trauma patient: outcomes for injured patients evaluated by emergency medical services but not transported to the hospital.| | PubMed
- Service: 2010 Western Trauma Association presidential address.| | PubMed
- Pitfalls in the evaluation and resuscitation of the trauma patient.| | PubMed
- Prospective randomized trial of LC+LCBDE vs ERCP/S+LC for common bile duct stone disease.| | PubMed
- Protein C depletion early after trauma increases the risk of ventilator-associated pneumonia.| | PubMed
- Where do we go from here? Interim analysis to forge ahead in violence prevention.| | PubMed
- Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis.| | PubMed
- Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathway.| | PubMed
- In brief. Management of the trauma patient.| | PubMed
- Pitfalls in the evaluation and management of the trauma patient.| | PubMed
- The spontaneous breathing pattern and work of breathing of patients with acute respiratory distress syndrome and acute lung injury.| | PubMed
- Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway?| | PubMed
- Field triage, and the fragile supply of "optimal resources" for the care of the injured patient.| | PubMed
- History of trauma field triage development and the American College of Surgeons criteria.| | PubMed
- Effects of tidal volume on work of breathing during lung-protective ventilation in patients with acute lung injury and acute respiratory distress syndrome.| | PubMed
- Work of breathing during lung-protective ventilation in patients with acute lung injury and acute respiratory distress syndrome: a comparison between volume and pressure-regulated breathing modes.| | PubMed
- Serum levels of Hsp60 correlate with the development of acute lung injury after trauma.| | PubMed
- Acute respiratory distress syndrome criteria in trauma patients: why the definitions do not work.| | PubMed
- An epidemic of methicillin-resistant Staphylococcus aureus soft tissue infections among medically underserved patients.| | PubMed
- The development of acute lung injury is associated with worse neurologic outcome in patients with severe traumatic brain injury.| | PubMed
- The effects of tidal volume demand on work of breathing during simulated lung-protective ventilation.| | PubMed
- Serum levels of Hsp 72 measured early after trauma correlate with survival.| | PubMed
- Multiinstitutional experience with the management of superior mesenteric artery injuries.| | PubMed
- Penetrating esophageal injuries: multicenter study of the American Association for the Surgery of Trauma.| | PubMed
- The effects of pressure control versus volume control assisted ventilation on patient work of breathing in acute lung injury and acute respiratory distress syndrome.| | PubMed
- Initial severity of metabolic acidosis predicts the development of acute lung injury in severely traumatized patients.| | PubMed
- Leukocytosis and free fluid are important indicators of isolated intestinal injury after blunt trauma.| | PubMed
- Gastric rupture and tension pneumoperitoneum complicating cardiopulmonary resuscitation: case report.| | PubMed
- Biological markers of acute lung injury: prognostic and pathogenetic significance.| | PubMed
- Trauma deaths in a mature urban vs rural trauma system. A comparison.| | PubMed
- Use of tissue oxygen tension measurements during resuscitation from hemorrhagic shock.| | PubMed
- Acute rupture of the diaphragm due to blunt trauma: diagnostic sensitivity and specificity of CT.| | PubMed
- Violence prevention involvement among trauma surgeons: description and preliminary evaluation.| | PubMed
- Risks, costs, and the expected complication of re-injury.| | PubMed
- Neurogenic pulmonary edema in fatal and nonfatal head injuries.| | PubMed
- High-risk behavior and the public burden for funding the costs of acute injury.| | PubMed
- Randomized study of algorithms for discontinuing tube thoracostomy drainage.| | PubMed
- Differential clearance of colloid and crystalloid solutions from the lung.| | PubMed
- The epidemiology of traumatic death. A population-based analysis.| | PubMed
- The etiology of missed cervical spine injuries.| | PubMed
- An evaluation of provider-related and disease-related morbidity in a level I university trauma service: directions for quality improvement.| | PubMed
- An analysis of errors causing morbidity and mortality in a trauma system: a guide for quality improvement.| | PubMed
- Can burst fractures be predicted from plain radiographs?| | PubMed
- Procuring donor organs for transplantation.| | PubMed
- Base deficit as an indicator of significant abdominal injury.| | PubMed
- The significance of critical care errors in causing preventable death in trauma patients in a trauma system.| | PubMed
- Prospective evaluation of epidural and intravenous administration of fentanyl for pain control and restoration of ventilatory function following multiple rib fractures.| | PubMed
- Organ procurement in patients with fatal head injuries. The fate of the potential donor.| | PubMed
- Blunt carotid artery dissection: incidence, associated injuries, screening, and treatment.| | PubMed
- Complications in evaluating abdominal trauma: diagnostic peritoneal lavage versus computerized axial tomography.| | PubMed
- The asymptomatic patient with suspected myocardial contusion.| | PubMed
- Use of end-tidal carbon dioxide tension for monitoring induced hypocapnia in head-injured patients.| | PubMed
- Pain management following trauma and burns.| | PubMed
- The economic burden of providing trauma care: what are the costs and who pays?| | PubMed
- Venous thromboembolism in patients with major trauma.| | PubMed
- Epidemiology and pathology of traumatic deaths occurring at a Level I Trauma Center in a regionalized system: the importance of secondary brain injury.| | PubMed
- Thoracotomy during trauma resuscitations--an appraisal by board-certified general surgeons.| | PubMed
- The impact of in-house surgeons and operating room resuscitation on outcome of traumatic injuries.| | PubMed
- Intra-abdominal injury following blunt trauma. Identifying the high-risk patient using objective risk factors.| | PubMed
- Base deficit as a guide to volume resuscitation.| | PubMed
- Major skeletal injuries in the obtunded blunt trauma patient: a case for routine radiologic survey.| | PubMed
- Video recording trauma resuscitations: an effective teaching technique.| | PubMed
- The role of pulmonary lymphatics in the clearance of hydrostatic pulmonary edema.| | PubMed
- Continuous epidural fentanyl analgesia: ventilatory function improvement with routine use in treatment of blunt chest injury.| | PubMed
- Impact of a trauma system on outcome of severely injured patients.| | PubMed
- Self-induced subcutaneous air mimicking a gas-forming infection.| | PubMed
- The prehospital use of external counterpressure: does MAST make a difference?| | PubMed
- Morphologic and physiologic correlates of increased extravascular lung water.| | PubMed
- Pulmonary extravascular fluid accumulation following intracranial injury.| | PubMed